Endocrine Abstracts

Background: Growth hormone (GH) deficiency, which causes visceral obesity and non-alcohol fatty liver disease, increases cardiovascular event risks. High-sensitivity C-reactive protein (hs-CRP), an inflammatory marker associated with increased cardiovascular risk, reportedly decreased after GH supplementation in GH-deficient patients, however, the association between GH secretion and inflammation remains unclear.Patients and Methods: We retrospectively i...

Background: (Pro)renin receptor[(P)RR] is a multi-functioning transmembrane protein which plays key roles in the regulation of tissue renin-angiotensin system (RAS). (P)RR is cleaved by furin to generate soluble (P)RR[s(P)RR], which is secreted into extracellular space. We previously reported that high blood concentration of s(P)RR indicates poor organ prognosis in several diseases. In this way, s(P)RR is expected as a candidate biomarker for reflecting the tissue RAS status, ...

Background: Growth hormone (GH) deficiency causes visceral obesity and fatty liver and increases cardiovascular event risks. Because serum high-sensitivity C-reactive protein (hs-CRP) levels, which has been used to estimate those risks, was reported to be decreased by GH supplementation therapy in GH deficient patients, it has been suggested that inflammatory processes might be activated in GH deficient state. However, the clinical factors associated with increased hs-CRP leve...

Introduction: TSH-secreting pituitary adenoma (TSHoma) sometimes brings on rare cause of hyperthyroidism because of its excessive TSH secretion. Though the first line of treatment for TSHoma is surgical removal of tumour, hyperthyroidism often causes perioperative thyroid storm. Here, we report a case of GH-TSH pituitary adenoma whose thyrotoxicosis was controlled by 5 days’ octoreotide (OCT) subcutaneous administration before surgery.Case report: A...